Towards MXenes’ biomedical applications by high-dimensional immune MAPping
(Project Number: 101086184)
Innovative biomedical applications of MXenes nanomaterials
MXenes are a new family of recently discovered 2D transition metal carbides, carbonitrides, and nitrides. The immune characterisation of the new materials on the basis of their physical-chemical and immunological properties will open up perspectives for the development of new therapeutic applications of nanomaterials in tissue engineering, cancer therapy, as antibacterial agents, and as immunomodulators. Funded by the Marie Skłodowska-Curie Actions programme, the MX-MAP project will develop key strategies for MXene medical applications. The long-term goal of MX-MAP is to create a pipeline using new MXene nanomaterials for the qualitative and quantitative assessment of immunological compatibility in biomedical applications. This international research/training programme aims to support the career development of young researchers with an interdisciplinary vision of science.
Project overview
Consortium
MX-MAP consortium put together experts in fields of chemistry, material science, nanotechnology, immunology, biology, high-throughput microscopy, photonics and medicine with the aim of overcoming current limitations in a variety of therapeutic approaches, including cancer photothermal therapy (PTT), photodynamic therapy (PDT), targeted drug delivery, regenerative medicine, and antibacterial strategies.
The new international network includes academic and industrial partners from EU MS (Italy, Germany, Latvia, Ireland), associated countries (Turkey, United Kingdom, Serbia, and Ukraine) with the involvement of associate academic partners from Third countries (USA, Canada, and Saudi Arabia) that will enable effective project realization, dissemination, and worldwide exploitation.
Secondments
The combination of leading researchers and enthusiastic research groups will enable to achieve all project tasks and reach the project aim. Research WPs will be realized via the inter-sectoral and interdisciplinary secondments with the aim of generating new and strengthening existing long-term collaborations. Inter-sectoral secondment will be used to convert innovative project ideas into real products and generation of new jobs in EU.
The Secondment structure of MX-MAP
This project has received funding from the European Union’s Horizon Europe research and innovation program under grant agreement No 101086184
Objectives
The main goal MX-MAP:
to facilitate R&I activities with complementary competences of participant organizations for development of new effective biomedical strategies using innovative biocompatible MXenes.
YUCOMAT international conference 2023, Montenegro: a section dedicated to MX-MAP!
Papers
1. Sergiy Kyrylenko, Inna Chorna, Zhanna Klishchova, Ilya Yanko, Anton Roshchupkin, Volodymyr Deineka, Kateryna Diedkova, Anastasia Konieva, Oksana Petrichenko, Irina Kube-Golovin, Gunther Wennemuth, Emerson Coy, Iryna Roslyk, Ivan Baginskiy, Veronika Zahorodna, Oleksiy Gogotsi, Benjamin Chacon, Luciana P. Cartarozzi, Alexandre L. R. Oliveira, Igor Iatsunskyi, Yury Gogotsi, Maksym Pogorielov. Elucidation of Potential Genotoxicity of MXenes Using a DNA Comet Assay. ACS Applied Bio Materials. 2024, 7, 12, 8351–8366. https://doi.org/10.1021/acsabm.4c01142
2. Mine Ensoy; Berfin Ilayda Ozturk; Demet Cansaran-Duman; Açelya Yilmazer. Inducing ferroptosis via nanomaterials: a novel and effective route in cancer therapy. JPhys Materials, 2024, Vol 7, Iss 3, p 032003 (2024) 10.1088/2515-7639/ad4d1e
3. Anastasia Konieva, Volodymyr Deineka, Kateryna Diedkova, Daniel Aguilar-Ferrer, Mykola Lyndin, Gunther Wennemuth, Viktoriia Korniienko, Sergiy Kyrylenko, Alexey Lihachev, Veronika Zahorodna, Ivan Baginskiy, Emerson Coy, Oleksiy Gogotsi, Agata Blacha-Grzec. MXene-Polydopamine-antiCEACAM1 Antibody Complex as a Strategy for Targeted Ablation of Melanoma. ACS Appl. Mater. Interfaces. 2024, 10.1021/acsami.4c08129
4. Sonata Adomaviciute-Grabusove, Anton Popov, Simonas Ramanavicius, Valdas Sablinskas, Kateryna Shevchuk, Oleksiy Gogotsi, Ivan Baginskiy, Yury Gogotsi and Arunas Ramanavicius. Nanoplastics: Immune Impact, Detection, and Internalization after Human Blood Exposure by Single‐Cell Mass Cytometry. ACS Nano. 2024, 10.1021/acsnano.4c02150
5. Laura Fusco, Arianna Gazzi, Linda Giro, Roman B. Schefer, Sènan Mickael D’Almeida, Roberta Cagliani, Martina Zoccheddu, Recep Uyar, Ömur Besbinar, Doğantan Çelik, Acelya Yilmazer, Denise M. Mitrano, Marco Orecchioni, Lucia Gemma Delogu. Nanoplastics: Immune Impact, Detection, and Internalization after Human Blood Exposure by Single‐Cell Mass Cytometry. Advanced Materials. 2024, 10.1002/adma.202413413
6. Kateryna Diedkova, Yevheniia Husak, Wojciech Simka, Viktoriia Korniienko, Bojan Petrovic, Anton Roshchupkin, Agnieszka Stolarczyk, Natalia Waloszczyk, Ilya Yanko, Kaspars Jekabsons, Maria Čaplovičová, Alexander D. Pogrebnjak, Veronika Zahorodna, Oleksiy Gogotsi, Iryna Roslyk, Ivan Baginskiy, Marko Radovic, Sanja Kojic, Una Riekstina, Maksym Pogorielov. Novel electrically conductive electrospun PCL-MXene scaffolds for cardiac tissue regeneration. Graphene and 2D Materials. 2023, 10.1007/s41127-023-00071-5
7. Kateryna Diedkova, Alexander D. Pogrebnjak, Sergiy Kyrylenko, Kateryna Smyrnova, Vladimir V. Buranich, Pawel Horodek, Pawel Zukowski, Tomasz N. Koltunowicz, Piotr Galaszkiewicz, Kristina Makashina, Vitaly Bondariev, Martin Sahul, Maria Čaplovičová, Yevhen. Polycaprolactone–MXene Nanofibrous Scaffolds for Tissue Engineering. ACS Appl. Mater. Interfaces. 2023, 10.1021/acsami.2c22780
8. Emel Kirbas Cilingir, Omur Besbinar, Linda Giro, Mattia Bartoli, Jose L. Hueso, Keenan J. Mintz, Yagmur Aydogan, Jordan M. Garber, Mine Turktas, Okan Ekim, Ahmet Ceylan, Mehmet Altay Unal, Mine Ensoy, Fikret Arı, Ozge Ozgenç Çinar, Berfin Ilayda Ozturk, C. Small Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment. Small. 2024, 10.1002/smll.202309283
9. Yilmazer, Açelya; Eroglu, Zafer; Gurcan, Cansu; Gazzi, Arianna; Ekim, Okan; Sundu, Buse; Gokce, Cemile; Ceylan, Ahmet; Giro, Linda; Unal, Mehmet Altay; Arı, Fikret; Ekicibil, Ahmet; Ozgenç Çinar, Ozge; Ozturk, Berfin Ilayda; Besbinar, Omur; Ensoy, Mine; Cansaran-Duman, Demet; Delogu, Lucia Gemma; Metin, Onder. Synergized photothermal therapy and magnetic field-induced hyperthermia via bismuthene for lung cancer combinatorial treatment. Materials Today Bio. 2023, 10.1016/j.mtbio.2023.100825
10. Fusco, Laura; Gazzi, Arianna; Shuck, Christopher E.; Orecchioni, Marco; Ahmed, Eiman I; Giro, Linda; Zavan, Barbara; Yilmazer, Açelya; Ley, Klaus; Bedognetti, Davide; Gogotsi, Yury; Delogu, Lucia Gemma. V4C3 MXene Immune Profiling and Modulation of T Cell-Dendritic Cell Function and Interaction. Small Methods. 2023, 10.1002/smtd.202300197